What is a drug? Are they always harmful? And might they be useful? This question, depending on how it is interpreted, can be controversial. But a careful look at the details, keeping our deeply internalized notions at bay, can yield surprising insights. Let us begin by thinking of natural products which are addictive in nature or can at least thought of as potentially addicting. Tea, coffee, tobacco, cannabis, cocaine, ephedrine, gingko, ginseng … a long list comes to mind.