Study Finds Natural Molecule in Coffee and Human Body Increases NAD+ Levels, Improves Muscle Function During Aging

A research consortium led by Nestlé Research in Switzerland and the Yong Loo Lin School of Medicine at the National University of Singapore (NUS Medicine) has discovered that the natural molecule trigonelline, present in coffee, fenugreek, and the human body, can improve muscle health and function. The study, which builds on a previous study that described novel mechanisms of human sarcopenia, found that trigonelline levels were lower in older people with sarcopenia. Pre-clinical models showed increased levels of NAD+, increased mitochondrial activity, and contributed to the maintenance of muscle function during aging. Trigonelline can be enhanced with various dietary precursors, such as the essential amino acid L-tryptophan (L-Trp) and vitamin B3 forms such as nicotinic acid (NA), nicotinamide (NAM), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN). The findings expand the current understanding of NAD+ metabolism and increase the potential of establishing interventions with NAD+-producing vitamins for both healthy longevity and age-associated diseases applications. Nutrition and physical activity are important lifestyle recommendations to maintain healthy muscles during aging.

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