Researchers have discovered that chronic caffeine consumption may impact brain plasticity and the effectiveness of repetitive transcranial magnetic stimulation (rTMS). Regular caffeine users may experience diminished long-term potentiation (LTP), a crucial process for learning and memory formation. This reduction in brain plasticity suggests that daily caffeine intake could influence cognitive functions and the success of rTMS treatments. The research highlights the need for more extensive research to understand the broader implications of habitual caffeine use on the brain. The study found that the difference in rTMS-induced motor evoked potentials (MEPs) between chronic caffeine users and non-users was more pronounced in non-caffeine users compared to caffeine-consuming counterparts. This suggests that regular intake of caffeine might be dampening the brain’s plasticity response. Further research is needed to deepen our understanding of these fundamental brain processes and guide the development of more effective therapeutic strategies for neuropsychiatric conditions.
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